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1

Optogenetic Approaches to Restoring Vision

Pan, Zhuo-Hua, Lu, Qi, Bi, Anding, Dizhoor, Alexander M., Abrams, Gary W.

Journal:

Annual Review of Vision Science

Year:

2015

Language:

english

File:

PDF, 731 KB

english, 2015

2

Ca2+-dependent conformational changes in bovine GCAP-2

Robert E. Hughes, James B. Hurley, Peter S. Brzovic, Alexander M. Dizhoor, Rachel E. Klevit

Journal:

Protein Science

Year:

1998

Language:

english

File:

PDF, 1.61 MB

english, 1998

3

Factors that affect regulation of cGMP synthesis in vertebrate photoreceptors and their genetic link to human retinal degeneration

Elena V. Olshevskaya, Alexandre N. Ermilov, Alexander M. Dizhoor

Journal:

Molecular and Cellular Biochemistry

Year:

2002

Language:

english

File:

PDF, 195 KB

english, 2002

4

Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase

Dizhoor, A., Ray, S, Kumar, S, Niemi, G, Spencer, M, Walsh, K., Philipov, P., Hurley, J., Stryer, L, Brolley, D

Journal:

Year:

1991

Language:

english

File:

PDF, 1.28 MB

english, 1991

5

Ceramide Kinase-Like (CERKL) Interacts with Neuronal Calcium Sensor Proteins in the Retina in a Cation-Dependent Manner

Nevet, M. J., Vekslin, S., Dizhoor, A. M., Olshevskaya, E. V., Tidhar, R., Futerman, A. H., Ben-Yosef, T.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2012

Language:

english

File:

PDF, 606 KB

english, 2012

6

Regulation of cGMP synthesis in photoreceptors: role in signal transduction and congenital diseases of the retina

Alexander M Dizhoor

Journal:

Cellular Signalling

Year:

2000

Language:

english

File:

PDF, 848 KB

english, 2000

7

Detailed Localization of Photoreceptor Guanylate Cyclase Activating Protein-1 and -2 in Mammalian Retinas using Light and Electron Microscopy

SHU KACHI, YUJI NISHIZAWA, ELENA OLSHEVSKAYA, AKIO YAMAZAKI, YOZO MIYAKE, TAKASHI WAKABAYASHI, ALEXANDER DIZHOOR, JIRO USUKURA

Journal:

Experimental Eye Research

Year:

1999

Language:

english

File:

PDF, 821 KB

english, 1999

8

Regulation of Photoreceptor Membrane Guanylyl Cyclases by Guanylyl Cyclase Activator Proteins

Alexander M. Dizhoor, James B. Hurley

Journal:

Year:

1999

Language:

english

File:

PDF, 173 KB

english, 1999

9

The binding of G proteins to immobilized delipidated rhodopsin

Alexander M. Dizhoor, Elina R. Nekrasova, Pavel P. Philippov

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 636 KB

english, 1989

10

Heterogenfous N-terminal acylation of photoreceptor proteins

J.B. Hurley, T. Neubert, A.M. Dizhoor, J. Chen, L.H. Ericsson, R.S. Johnson, K.A. Walsh

Journal:

Experimental Eye Research

Year:

1992

Language:

english

File:

PDF, 102 KB

english, 1992

11

Study on the met-tRNA-binding activity in krebs-2 cells infected with encephalomyocarditis virus

A.M. Dizhoor, T.Yu. Ugarova

Journal:

Year:

1981

Language:

english

File:

PDF, 358 KB

english, 1981

12

The effect of rhodopsin phosphorylation on the light-dependent activation of phosphodiesterase from bovine rod outer segments

V.Yu. Arshavsky, A.M. Dizhoor, I.K. Shestakova, P.P. Philippov

Journal:

Year:

1985

Language:

english

File:

PDF, 272 KB

english, 1985

13

Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration

Anding Bi, Jinjuan Cui, Yu-Ping Ma, Elena Olshevskaya, Mingliang Pu, Alexander M. Dizhoor, Zhuo-Hua Pan

Journal:

Year:

2006

Language:

english

File:

PDF, 765 KB

english, 2006

14

Mg2+/Ca2+cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase

Alexander M. Dizhoor, Elena V. Olshevskaya, Igor V. Peshenko

Journal:

Molecular and Cellular Biochemistry

Year:

2010

Language:

english

File:

PDF, 464 KB

english, 2010

15

Backbone1H,13C, and15N resonance assignments of guanylyl cyclase activating protein-1, GCAP1

Lim, Sunghyuk, Peshenko, Igor V., Dizhoor, Alexander M., Ames, James B.

Journal:

Biomolecular NMR Assignments

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

16

Identification of Target Binding Site in Photoreceptor Guanylyl Cyclase-activating Protein 1 (GCAP1)

Peshenko, I. V., Olshevskaya, E. V., Lim, S., Ames, J. B., Dizhoor, A. M.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 5.16 MB

english, 2014

17

Regulation Of Photoreceptor Guanylyl Cyclase By Ca2+/Mg2+ Exchange In GCAPs

Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 41 KB

english, 2009

18

ST. THOMAS'S HOSPITAL. Cancer of the Tongue; Removal by Ligature. (Under the care of Mr. SOLLY.)

Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.

Journal:

Year:

1852

Language:

english

File:

PDF, 220 KB

english, 1852

19

The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator

Journal:

Year:

1994

Language:

english

File:

PDF, 3.94 MB

english, 1994

20

Effects of Ca 2+ , Mg 2+ , and Myristoylation on Guanylyl Cyclase Activating Protein 1 Structure and Stability †

Lim, Sunghyuk, Peshenko, Igor, Dizhoor, Alexander, Ames, James B.

Journal:

Year:

2009

Language:

english

File:

PDF, 1.04 MB

english, 2009

21

Enzymatic Properties and Regulation of the Native Isozymes of Retinal Membrane Guanylyl Cyclase (RetGC) from Mouse Photoreceptors

Peshenko, Igor V., Olshevskaya, Elena V., Savchenko, Andrey B., Karan, Sukanya, Palczewski, Krzysztof, Baehr, Wolfgang, Dizhoor, Alexander M.

Journal:

Year:

2011

Language:

english

File:

PDF, 2.88 MB

english, 2011

22

Retinal Degeneration 3 (RD3) Protein Inhibits Catalytic Activity of Retinal Membrane Guanylyl Cyclase (RetGC) and Its Stimulation by Activating Proteins

Peshenko, Igor V., Olshevskaya, Elena V., Azadi, Seifollah, Molday, Laurie L., Molday, Robert S., Dizhoor, Alexander M.

Journal:

Year:

2011

Language:

english

File:

PDF, 2.52 MB

english, 2011

23

Factors that Determine Ca 2+ Sensitivity of Photoreceptor Guanylyl Cyclase. Kinetic Analysis of the Interaction between the Ca 2+ -Bound and the Ca 2+ -Free Guanylyl Cyclase Activating Proteins (GCAPs) and Recombinant Photoreceptor Guanylyl Cyclase 1 (RetGC-1) †

Peshenko, Igor V., Moiseyev, Gennadiy P., Olshevskaya, Elena V., Dizhoor, Alexander M.

Journal:

Year:

2004

Language:

english

File:

PDF, 172 KB

english, 2004

24

Activation of Retinal Guanylyl Cyclase RetGC1 by GCAP1: Stoichiometry of Binding and Effect of New LCA-Related Mutations

Peshenko, Igor V., Olshevskaya, Elena V., Yao, Suxia, Ezzeldin, Hany H., Pittler, Steven J., Dizhoor, Alexander M.

Journal:

Year:

2010

Language:

english

File:

PDF, 2.86 MB

english, 2010

25

cGMP Accumulation Causes Photoreceptor Degeneration in CNG Channel Deficiency: Evidence of cGMP Cytotoxicity Independently of Enhanced CNG Channel Function

Xu, J., Morris, L., Thapa, A., Ma, H., Michalakis, S., Biel, M., Baehr, W., Peshenko, I. V., Dizhoor, A. M., Ding, X.-Q.

Journal:

Journal of Neuroscience

Year:

2013

Language:

english

File:

PDF, 2.90 MB

english, 2013

26

Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors

Mendez, A., Burns, M. E., Sokal, I., Dizhoor, A. M., Baehr, W., Palczewski, K., Baylor, D. A., Chen, J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 339 KB

english, 2001

27

Activation and Inhibition of Photoreceptor Guanylyl Cyclase by Guanylyl Cyclase Activating Protein 1 (GCAP-1): THE FUNCTIONAL ROLE OF Mg2+/Ca2+ EXCHANGE IN EF-HAND DOMAINS

Peshenko, I. V., Dizhoor, A. M.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 845 KB

english, 2007

28

Binding of Guanylyl Cyclase Activating Protein 1 (GCAP1) to Retinal Guanylyl Cyclase (RetGC1): THE ROLE OF INDIVIDUAL EF-HANDS

Peshenko, I. V., Olshevskaya, E. V., Dizhoor, A. M.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.17 MB

english, 2008

29

Mapping Functional Domains of the Guanylate Cyclase Regulator Protein, GCAP-2

Olshevskaya, E. V., Boikov, S., Ermilov, A., Krylov, D., Hurley, J. B., Dizhoor, A. M.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 1.06 MB

english, 1999

30

Constitutive Excitation by Gly90Asp Rhodopsin Rescues Rods from Degeneration Caused by Elevated Production of cGMP in the Dark

Woodruff, M. L., Olshevskaya, E. V., Savchenko, A. B., Peshenko, I. V., Barrett, R., Bush, R. A., Sieving, P. A., Fain, G. L., Dizhoor, A. M.

Journal:

Journal of Neuroscience

Year:

2007

Language:

english

File:

PDF, 712 KB

english, 2007

31

Cloning, Sequencing, and Expression of a 24-kDa Ca2+-binding Protein Activating Photoreceptor Guanylyl Cyclase

Dizhoor, A. M., Olshevskaya, E. V., Henzel, W. J., Wong, S. C., Stults, J. T., Ankoudinova, I., Hurley, J. B.

Journal:

Journal of Biological Chemistry

Year:

1995

Language:

english

File:

PDF, 832 KB

english, 1995

32

Ca 2+ -dependent Conformational Changes in Guanylyl Cyclase-activating Protein 2 (GCAP-2) Revealed by Site-specific Phosphorylation and Partial Proteolysis

Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 1.03 MB

english, 2004

33

Guanylyl Cyclase-activating Proteins (GCAPs) Are Ca2+/Mg2+ Sensors: IMPLICATIONS FOR PHOTORECEPTOR GUANYLYL CYCLASE (RetGC) REGULATION IN MAMMALIAN PHOTORECEPTORS

Peshenko, I. V., Dizhoor, A. M.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 669 KB

english, 2004

34

Recoverin immunoreactivity in mammalian cone bipolar cells

Milam, Ann H., Dacey, Dennis M., Dizhoor, Alexander M.

Journal:

Visual Neuroscience

Year:

1993

Language:

english

File:

PDF, 1.48 MB

english, 1993

35

A Role for GCAP2 in Regulating the Photoresponse: GUANYLYL CYCLASE ACTIVATION AND ROD ELECTROPHYSIOLOGY IN GUCA1B KNOCK-OUT MICE

Makino, C. L., Peshenko, I. V., Wen, X.-H., Olshevskaya, E. V., Barrett, R., Dizhoor, A. M.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.07 MB

english, 2008

36

Three-dimensional Structure of Guanylyl Cyclase Activating Protein-2, a Calcium-sensitive Modulator of Photoreceptor Guanylyl Cyclases

Ames, J. B., Dizhoor, A. M., Ikura, M., Palczewski, K., Stryer, L.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 1.75 MB

english, 1999

37

Ca2+ and Mg2+ Binding Properties of GCAP-1: EVIDENCE THAT Mg2+-BOUND FORM IS THE PHYSIOLOGICAL ACTIVATOR OF PHOTORECEPTOR GUANYLYL CYCLASE

Peshenko, I. V., Dizhoor, A. M.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.12 MB

english, 2006

38

Activation of Retinal Guanylyl Cyclase-1 by Ca2+-binding Proteins Involves Its Dimerization

Yu, H., Olshevskaya, E., Duda, T., Seno, K., Hayashi, F., Sharma, R. K., Dizhoor, A. M., Yamazaki, A.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 840 KB

english, 1999

39

Constitutive Activation of Photoreceptor Guanylate Cyclase by Y99C Mutant of GCAP-1: POSSIBLE ROLE IN CAUSING HUMAN AUTOSOMAL DOMINANT CONE DEGENERATION

Dizhoor, A. M., Boikov, S. G., Olshevskaya, E. V.

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 704 KB

english, 1998

40

The Membrane Guanylyl Cyclase, Retinal Guanylyl Cyclase-1, Is Activated through Its Intracellular Domain

Laura, R. P., Dizhoor, A. M., Hurley, J. B.

Journal:

Journal of Biological Chemistry

Year:

1996

Language:

english

File:

PDF, 152 KB

english, 1996

41

Calcium Binding, but Not a Calcium-Myristoyl Switch, Controls the Ability of Guanylyl Cyclase-activating Protein GCAP-2 to Regulate Photoreceptor Guanylyl Cyclase

Olshevskaya, E. V., Hughes, R. E., Hurley, J. B., Dizhoor, A. M.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 978 KB

english, 1997

42

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

Jiang, L., Zhang, H., Dizhoor, A. M., Boye, S. E., Hauswirth, W. W., Frederick, J. M., Baehr, W.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 776 KB

english, 2011

43

Inactivation of EF-hands Makes GCAP-2 (p24) a Constitutive Activator of Photoreceptor Guanylyl Cyclase by Preventing a Ca2+-induced "Activator-to-Inhibitor" Transition

Dizhoor, A. M., Hurley, J. B.

Journal:

Journal of Biological Chemistry

Year:

1996

Language:

english

File:

PDF, 581 KB

english, 1996

44

Mapping Sites in Guanylyl Cyclase Activating Protein-1 Required for Regulation of Photoreceptor Membrane Guanylyl Cyclases

Krylov, D. M., Niemi, G. A., Dizhoor, A. M., Hurley, J. B.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 642 KB

english, 1999

45

Modulation of Phosphodiesterase6 Turnoff during Background Illumination in Mouse Rod Photoreceptors

Woodruff, M. L., Janisch, K. M., Peshenko, I. V., Dizhoor, A. M., Tsang, S. H., Fain, G. L.

Journal:

Journal of Neuroscience

Year:

2008

Language:

english

File:

PDF, 657 KB

english, 2008

46

Night Blindness and the Mechanism of Constitutive Signaling of Mutant G90D Rhodopsin

Dizhoor, A. M., Woodruff, M. L., Olshevskaya, E. V., Cilluffo, M. C., Cornwall, M. C., Sieving, P. A., Fain, G. L.

Journal:

Journal of Neuroscience

Year:

2008

Language:

english

File:

PDF, 513 KB

english, 2008

47

Retinal Guanylyl Cyclase Isozyme 1 Is the Preferential In Vivo Target for Constitutively Active GCAP1 Mutants Causing Congenital Degeneration of Photoreceptors

Olshevskaya, E. V., Peshenko, I. V., Savchenko, A. B., Dizhoor, A. M.

Journal:

Journal of Neuroscience

Year:

2012

Language:

english

File:

PDF, 2.96 MB

english, 2012

48

Determining consequences of retinal membrane guanylyl cyclase (RetGC1) deficiency in human Leber congenital amaurosis en route to therapy: residual cone-photoreceptor vision correlates with biochemical properties of the mutants

Jacobson, S. G., Cideciyan, A. V., Peshenko, I. V., Sumaroka, A., Olshevskaya, E. V., Cao, L., Schwartz, S. B., Roman, A. J., Olivares, M. B., Sadigh, S., Yau, K.-W., Heon, E., Stone, E. M., Dizhoor,

Journal:

Human Molecular Genetics

Year:

2013

Language:

english

File:

PDF, 597 KB

english, 2013

49

Calcium-Myristoyl Tug Is a New Mechanism for Intramolecular Tuning of Calcium Sensitivity and Target Enzyme Interaction for Guanylyl Cyclase-activating Protein 1

Peshenko, Igor V., Olshevskaya, Elena V., Lim, Sunghyuk, Ames, James B., Dizhoor, Alexander M.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 3.15 MB

english, 2012

50

Evaluating the Role of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Domains in Binding Guanylyl Cyclase-activating Proteins (GCAPs)

Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.24 MB

english, 2015

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